Accurately Predict Toxicity Issues before They Impact Your Drug Development Process
Early, accurate, and robust detection of compound toxicity streamlines the drug development process by saving time, money, and resources. Three requirements of effective and timely in vitro prediction are:
- Relevance: Test substrate must provide a contextually relevant cellular environment
- Quality and availability: Material must be of high quality, consistent functionality, and available on demand at any volume
- Ease of use: Models must integrate into the testing cascade for prospective screens and retrospective mechanistic studies
Human-derived Cardiac, Hepatic, and Neuronal Cells Enable In Vitro Toxicity Prediction
CDI’s tissue cells meet the requirements for relevant, accurate toxicity detection. Derived from human induced pluripotent stem cells (iPSCs), our iCell® products recapitulate the native human cellular environment, are manufactured at high quality and industrial volumes, and incorporate seamlessly into drug development workflows with any number of commonly used platforms and techniques.
iCell Cardiomyocytes and iCell Cardiomyocytes2
With 75+ publications, ~25 application protocols/notes, and demonstrated predictivity for structural, functional, on-target, and off-target toxicity testing, iCell Cardiomyocytes and iCell Cardiomyocytes2 are the tools of choice for early detection of cardiotoxic side effects. Complete the form below to receive a summary of and links to iCell Cardiomyocytes publications.
Prolonged culture using human-derived iCell Hepatocytes enable acute and chronic toxicity studies. Demonstrated 3D compatibility extends the utility of hepatocyte-based investigations. Complete the form below to receive an overview of the unique utility of iCell Hepatocytes.
iCell Neuronal Portfolio
The demonstrated utility of iCell Neurons in developmental, functional, degenerative toxic endpoints is extended to subtype specific neurons with iCell DopaNeurons and the early access iCell GlutaNeurons. Complete the form below to receive an overview of these highly useful and distinct neuronal cells.