Products & Services

Accurately Predict Toxicity Issues before They Impact Your Drug Development Process

Early, accurate, and robust detection of compound toxicity streamlines the drug development process by saving time, money, and resources. Three requirements of effective and timely in vitro prediction are:

  • Relevance: Test substrate must provide a contextually relevant cellular environment
  • Quality and availability: Material must be of high quality, consistent functionality, and available on demand at any volume
  • Ease of use: Models must integrate into the testing cascade for prospective screens and retrospective mechanistic studies

Human-derived Cardiac, Hepatic, and Neuronal Cells Enable In Vitro Toxicity Prediction

CDI’s tissue cells meet the requirements for relevant, accurate toxicity detection. Derived from human induced pluripotent stem cells (iPSCs), our iCell® products recapitulate the native human cellular environment, are manufactured at high quality and industrial volumes, and incorporate seamlessly into drug development workflows with any number of commonly used platforms and techniques.

iCell Cardiomyocytes and iCell Cardiomyocytes2

With 75+ publications, ~25 application protocols/notes, and demonstrated predictivity for structural, functional, on-target, and off-target toxicity testing, iCell Cardiomyocytes and iCell Cardiomyocytes2 are the tools of choice for early detection of cardiotoxic side effects. Complete the form below to receive a summary of and links to iCell Cardiomyocytes publications.

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From left: iCell Cardiomyocytes; Maestro MEA recordings; xCELLigence RTCA-Cardio recordings. iCell Cardiomyocytes and iCell Cardiomyocytes2 form functional tissue layers for robust, reliable, and predictive interrogation.

iCell Hepatocytes

Prolonged culture using human-derived iCell Hepatocytes enable acute and chronic toxicity studies. Demonstrated 3D compatibility extends the utility of hepatocyte-based investigations. Complete the form below to receive an overview of the unique utility of iCell Hepatocytes.

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From left: Ketoconazole toxicity testing with iCell Hepatocytes 2.0 spheres; Acute and chronic hepatotoxicity testing. iCell Hepatocytes 2.0 provide multiple methods for relevant hepatotoxicity testing.

 

iCell Neuronal Portfolio

The demonstrated utility of iCell Neurons in developmental, functional, degenerative toxic endpoints is extended to subtype specific neurons with iCell DopaNeurons and the early access iCell GlutaNeurons. Complete the form below to receive an overview of these highly useful and distinct neuronal cells.

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From left: iCell GlutaNeurons; Electrical activity readouts; Glutamate-induced excitotoxicity. The iCell neuronal portfolio offers easy access to previously unreachable human neurobiology.

 

Complete the Form for iCell-fueled Case Studies