Products & Services

MyCell Disease & Diversity Products

MyCell® Disease and Diversity Products are manufactured from a variety of healthy and diseased donor backgrounds. These human iPS cell-derived differentiated cells are assay-ready and exhibit phenotypes that enable drug discovery, toxicity testing, and disease modeling applications.

Benefits

  • Flexible experimental design: Choose from a wide variety of donor backgrounds, and a large suite of proven application protocols
  • Rapid reliable data: Assay-ready cells do not require differentiation
  • Confidence in your results: Isogenic and/or matched controls are available

Use the search tool below to select your cells of interest from our extensive range of banked, disease-relevant or control iPS cell lines. Next, pick from six available differentiated cell types and choose the desired package size and quantity. We will provide you with a prompt price quotation.

Glossary of Terms

 Age

Applies to the age in years of the donor when cells were harvested for reprogramming into iPSC.  For grouping decades are used instead of a specific year.

Age at Onset

Applies to donors that have been diagnosed with a specific disease or syndrome.  The age in years when the diagnosis was made and a decade value is used instead of the specific year.

Collection

Describes the cell bank source for the iPSCs used as source material for differentiation into the offered cell types. Collections include CIRM which is the California Institute for Regenerative Medicine, cell lined developed at Cellular Dynamics, and additional sources which will be added in a continuing basis.

dbSNP Reference

The Ensembl reference number for a particular SNP contained within the Ensembl database.  Ensembl is a joint database project between the Wellcome Trust Sanger Institute and the European Bioinformatics Institute providing stable comprehensive human genome sequence information.

Ethnicity (Ethnic Group)

A classification of people who share a common and distinctive culture, religion, language or similar characteristics.  Ethnicity differs from social group in that it is primarily an inherited status.

Genotype

The genetic makeup of an individual or cell.  For use in this catalog genotype refers to the genetic variants that determine an observable trait (phenotype) or dictated by the engineered DNA sequence within a created disease model.

OMIM

Online Mendelian Inheritance in Man (OMIM®) is a continuously updated catalog of human genes and genetic disorders and traits, with particular focus on the molecular relationship between genetic variation and phenotypic expression. It is thus considered to be a phenotypic companion to the Human Genome Project. OMIM is a continuation of Dr. Victor A. McKusick’s Mendelian Inheritance in Man, which was published through 12 editions, the last in 1998. OMIM is currently biocurated at the McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine.

  • OMIM Disease – This number refers to the OMIM reference number for a specific phenotype or disease association that has a genetic basis.
  • OMIM Gene – This number refers to the OMIM reference number for a gene or genetic loci. The loci or gene may be autosomal, X-linked, Y-linked or mitochondrial.

Phenotype

The clinical or biochemical expression of a gene or genotype in a human individual or cell.

Race

A division or classification of humankind where a race is a population partially isolated reproductively or geographically from other populations and whose members share a high degree of physical and genetic similarity.

Red Cell Type

Refers to the blood type of the donor according to the ABO blood group system.

Sex

Sex in this use refers to the biological status of the donor and has no basis on sexual alignment or self-designation but based primarily on the makeup of the sex chromosomes

Starting Material

Refers to the type of sample provided to the collection either as fibroblasts (skin cells), PBMCs (peripheral blood mononuclear cells), other or unclassified sources.

Zygosity

The degree of similarity for a certain trait or allele between the two chromosomes of a diploid organism at a given locus.  Types of zygosity include:

  • Homozygous – A homozygous trait or gene is identical on both chromosomes.
  • Heterozygous – In heterozygotes the trait or gene is non-identical on each chromosome and different alleles are present at that locus.
  • Hemizygous – In a cell where one copy of a gene is deleted or is found on a sex chromosome that trait or gene is viewed as hemizygous.
  • Nullizygous – Traits or genes that have both genes deleted or deletions occur in a hemizygous gene are said to be nullizygous.

 

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