iCell® Motor Neurons
Moving Research Forward with New Model Systems
Innervation of muscle fibers by spinal motor neurons is essential for controlling muscle contraction and ultimately coordinated movement. Neurodegenerative diseases such as ALS and SMA are a result of the progressive degeneration of motor neurons that leads to an uncoupling of this process. In order to provide researchers with a model system for understanding basic motor neuron biology and to develop treatments for these diseases, CDI is now offering iCell® Motor Neurons. iCell Motor Neurons are a highly pure population of human spinal motor neurons derived from induced pluripotent stem (iPS) cells with the following features:
- Fully differentiated, ≥87% (β-III tubulin) pure population of primarily cholinergic human neurons (≥55% Isl1/2).
- Display typical neuronal morphology with branching neurites and remain viable for an extended culture period (≥14 days).
- Express markers characteristic of motor neurons.
- Available in commercial quantities
- Easy to use: Simply thaw and plate
These cells provide a reliable source of human neurons suitable for use within:
- Basic & Translational Research: Studying neurodegenerative diseases like ALS & SMA, myelination/demyelination, and neurogenesis
- Drug Discovery: For diseases such as ALS and SMA
- Bioengineering: Development of neuromuscular junction models
- Applied Markets: BoNT testing
- Toxicology and Safety Pharma: For testing chemical warfare agents, effects of chemical pesticides, etc.