iCell® GABANeurons
Advancing New Paradigms in Neuroscience Research
Traditional neuroscience research tools consist largely of rodent primary cell cultures and animal models, which are labor-intensive, costly, and poorly reflective of native human biology. iCell® GABANeurons represent a relevant human in vitro system for modeling and interrogating complex neurological processes and diseases.
iCell GABANeurons are iPS cell-derived mixed populations of human cerebral cortical neurons that exhibit native electrical and biochemical activity. They overcome limitations of existing models by providing the following:
- >95% pure population of primarily GABAergic (inhibitory) neurons
- Rapid formation of neural networks and functional synapses
- Expression of relevant neurological therapeutic targets and pathways
- Long-term viability and demonstrated reproducibility
- Reliable supply in cryopreserved format
More Data, More Publications, More Solutions
There is a broad range of peer-reviewed publications and CDI application protocols and applications notes to support your research goals including:
- Alzheimer’s disease research and drug discovery
Functional tau and β-amyloid toxicity pathways, long-term viability, and flexible product format enable high-throughput screening for novel drug candidates - Autism disease research
Demonstrated prefrontal cortex ionotropic glutamate receptors, GABAA receptor, and synaptic functionality drive interrogation of neurological diseases, such as autism - Infectious disease studies
Susceptibility to varicella zoster virus infection and ability to maintain viral latency and reactivation - Therapeutic potency testing
High sensitivity, dose-response, and biological responses to Clostridium botulinum neurotoxin (BoNT) aid replacement of the gold-standard mouse bioassay for BoNT potency testing - Neurotoxicity assessment
Compatibility with a wide range of high-content, high-throughput platforms enables assessment of pharmaceutical and environmental neurotoxicity