Products & Services

iCell® DopaNeurons

Go Straight to the Source of Human Disease Biology

iCell® DopaNeurons are iPS cell-derived human midbrain floorplate dopaminergic neurons, differentiated in protocols licensed and adapted from the Lorenz Studer lab (Memorial Sloan Kettering) and industrialized for scale at CDI.

Best-in-Class Biology

iCell DopaNeurons exhibit the relevant biology and functionality to advance research and preclinical studies for devastating neurological disorders:

  • Fully differentiated, >80% pure midbrain DA neurons
  • Expression of relevant midbrain DA neuron markers (e.g. Lmx1, FoxA2, and TH)
  • Functional release and uptake of dopamine
  • Appropriate electrophysiology and pacemaker-like activity:
    • Spontaneous and evoked action potentials
    • Excitatory post-synaptic currents
    • Sodium ion and potassium ion channel currents
  • Compatible with a wide range of biochemical and cell-based assays:
    • Cell viability
    • Cell mitophagy
    • Calcium signaling
    • Neurite outgrowth and retraction

For Parkinson’s disease modeling, please also see the isogenic MyCell® DopaNeurons (A53T)

  • Ordering Information
    Catalog # Description Quantity
    R1088 iCell DopaNeurons Kit, 01279

    Each kit contains:

    • Cryopreserved iCell DopaNeurons
    • 100 ml Neural Base Medium 1
    • 2 ml Neural Supplement B
    • 1 ml Nervous System Supplement
    • User’s Guide
    ≥1 x 106
    Viable Cells/Vial
    Request Quote
    R1032 iCell DopaNeurons Kit, 01279

    Each kit contains:

    • Cryopreserved iCell DopaNeurons
    • 100 ml Neural Base Medium 1
    • 2 ml Neural Supplement B
    • 1 ml Nervous System Supplement
    • User’s Guide
    ≥5 x 106
    Viable Cells/Vial
    Request Quote
    M1029 iCell Neural Supplement B

    Dopaminergic neurons medium supplement, serum-free

    2 ml Request Quote
    M1031 iCell Nervous System Supplement

    Growth factor supplement for neuronal cell types

    1 ml Request Quote