Products & Services

iCell® Cardiomyocytes2

Optimized for faster recovery and increased scientific throughput

iCell® Cardiomyocytes2  are an enhanced version of our extensively validated and predictive iCell Cardiomyocytes product. While they share most performance characteristics and boast advantages similar to those of the original iCell Cardiomyocytes product, iCell Cardiomyocytes2 have been optimized for faster recovery upon reanimation from cryopreservation. With iCell Cardiomyocytes2, you can increase scientific throughput while minimizing experimental handling and laboratory time.

  • Rapid recovery: Rebound quickly from cryopreservation to generate a mixture of spontaneously electrically active atrial-, nodal-, and ventricular-like myocytes
  • Electrophysiological response: Possess typical electrophysiological characteristics and exhibit expected electrophysiological and biochemical responses upon exposure to exogenous agents
  • Accelerated workflow: Provide a reliable and more rapidly implementable source of human cardiomyocytes for use in targeted drug discovery, toxicity testing, and other life science research applications

A Multitude of Applications

iCell Cardiomyocytes2 have demonstrated utility for electrophysiological and biochemical assays in toxicology, drug discovery, and basic life science research applications. Contact our Technical Support team for information on using iCell Cardiomyocytes2 in these types of studies.

  • Multielectrode array (MEA) recordings
  • Impedance-based measurements
Detecting Ion Channel Block

iCell Cardiomyocytes2 Provide an Accurate System for Detecting Ion Channel Block
Panels A and B show the expected increase in the field potential duration blocking IKr with E-4031. Panels C and D show the expected decrease in the field potential duration blocking the L-type calcium channels with nifedipine. iCell Cardiomyocytes2 were exposed to the indicated compounds at the concentrations listed and the effects quantified ± SEM.

 

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iCell Cardiomyocytes2 Capture Phenotypic Responses across Different Classes of Cardioactive Compounds
Modulating ion channel and GPCR activity alters the spontaneous contractile activity of iCell Cardiomyocytes2. Blocking IKr, ICa-L, and INa with E4031, nifedipine, and mexiletine and stimulating the β-adrenergic pathway with isoproterenol produced the expected effects on the beat waveforms.