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September 2017

Exploring the Role of iPSC-Cardiomyocytes in Drug Discovery and Safety Assessment

Webinars
September 7 | 11:00 am CDT - 12:00 pm CDT

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly utilized in drug discovery, safety assessment of pharmaceutical compounds, and studies of disease mechanisms. The opportunity to measure the contractility, viability, and electrophysiology of these cells in real time over extended periods provides researchers with additional mechanistic insights into the roles cardiomyocytes play in both normal development and cardiac disease, in addition to providing incisive information regarding drug efficacy and toxicity. In this special webinar, scientists using hiPSC-CMs will describe novel…

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January 2017

Modeling Lipid and Glucose Metabolism Using Human iPSC-derived Hepatocytes

Webinars
January 25 | 10:00 am CDT - 11:00 am CDT

The study of metabolic disease is changing as limitations of classical in vitro cell models are increasingly evident, causing investigators to search for improved alternatives. Induced pluripotent stem cells (iPSCs) are the logical alternative for advancing basic biology and applied biomedical research through the development of relevant human cell models. Recapitulating native physiological behavior is the ideal scenario for phenotypic screening and target identification—techniques that are paramount to both academic and biopharmaceutical researchers. Join us for this GEN webinar, where we will focus…

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December 2016

Advances in Modeling Human Diseases Using Induced Pluripotent Stem Cell-derived Cellular Models

Webinars
December 14, 2016 | 9:30 am CDT - 10:30 pm CDT

A major hurdle in developing relevant disease models for drug discovery is access to the healthy and diseased tissue of interest; induced pluripotent stem cell (iPSC) technology addresses this problem affording access to biologically relevant human tissues in essentially unlimited quantities. In this webinar, we will describe examples of how iPSC-derived disease cell models can be used to understand pathophysiological pathways in disease. Among the examples we will highlight are models of diseases induced in iPSC-derived cells from a healthy…

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November 2016

Using Spheroid Models to Develop Relevant High-throughput Assays with Quantitative Endpoints

Webinars
November 3, 2016 | 10:00 am CDT - 11:00 am CDT

Significant advances in automated microscopy, imaging, and biological models are delivering more predictive, physiologically-relevant measurements for drug discovery and environmental toxicity applications. Yet, implementation challenges have been a deterrent for utilizing 3D spheroid models. This webinar will explore the use and analysis of cancer spheroid models, as well as iPSC-derived hepatocyte and cardiomyocyte spheroids for toxicity assessment and demonstrate that historical barriers have been overcome. Join us to learn about: Selecting products and solutions for implementation of 3D spheroid models…

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June 2016

Refining Toxicity Testing through Advances in Human iPSC Technology

Webinars
June 9, 2016 | 10:00 am CDT - 11:00 am CDT

Learn how advances in human induced pluripotent stem cell (iPSC) technology enable early detection and avoidance of neuro-, cardio-, and hepatotoxicity during drug development. The Cellular Dynamics line of iCell® products are fully differentiated human cells derived from iPSCs. iCell GlutaNeurons are a population of excitatory neurons that bring previously inaccessible human biology to the lab bench for both discovery and toxicity (seizurogenic) investigations. iCell Hepatocytes 2.0 maintain appropriate function longer than existing models and over extended culture periods, thus…

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March 2016

The Promise and Challenges of iPSC Modeling in Parkinson’s Disease

Webinars
March 17, 2016 | 10:30 am CDT - 11:30 am CDT

Abstract Given the challenges of replicating Parkinson’s disease in animal models, returning to models that are human-based and highly clinically characterized may provide the most successful path forward. There is a critical need to differentiate Lewy body Parkinson’s disease from other non-Lewy body forms of parkinsonism. This is important because the underlying molecular pathomechanisms, and hence potential therapeutic targets, are unlikely to be similar for both. One exciting new avenue regarding modeling human disease is the use of induced pluripotent…

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December 2015

Advancing PD Cell Therapy: Transplanting Cryopreserved iPSC-derived Neurons

Webinars
December 8, 2015 | 10:00 am CDT

Abstract Cryopreservation of post-mitotic, induced pluripotent stem cell-derived midbrain lineage dopamine neurons (iPSC-mDA) is a significant advancement for cell therapy in Parkinson’s disease. Here, we demonstrate that cryopreserved iPSC-mDA neurons are reliably thawed with excellent viability and maintain biochemical and physiological signatures indicative of human midbrain dopamine neurons. We also examined the engraftment potential of iPSC-mDA neurons after transplantation into both the rodent brain up to 6-months post-grafting and the nonhuman primate brain up to 3-months post-transplantation. Immunohistochemical analysis demonstrated…

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CellPress Webinar: New Probes and Sensors in Neurobiology

Webinars
December 7, 2015 | 11:00 am CDT - 12:00 pm CDT

Current efforts in neuroscience are being devoted to mapping activity in defined cells and to developing tools and methods that allow the interrogation of specific circuits in great detail. In this webinar, we will hear from young scientists who will present a snapshot of different techniques and their potential future applications. Viviana Gradinaru will discuss methods to facilitate visualization of circuits and delivery of viral vectors to the brain, Adam Cohen will present advances on all-optical neural imaging, and Bianxiao…

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July 2015

Investigative in vitro Drug Toxicology with Human iPSC-derived Cardiomyocytes

Webinars
July 22, 2015 | 11:00 am CDT

Abstract: Human induced pluripotent stem cells (iPSCs) bring human biology into pre-clinical aspects of drug discovery. iPSC-derived cardiomyocytes have emerged as useful tools for detecting and predicting cardiotoxicity and proarrhythmia. The relevant biology of these cardiomyocytes provides a holistic reagent for testing numerous aspects of structural and functional biology, including on- and off-target toxicities. Syncytial hiPSC-derived cardiomyocytes exhibit highly-regular spontaneous beating with low sample-to-sample variation, which makes them adaptable to real-time functional screening in label-free multiwell platforms and facilitates studies…

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May 2015

Accurate Prediction of On- and Off-target Cardiotoxicity with Human iPSC-Derived Cardiomyocytes

Webinars
May 27, 2015 | 10:00 am CDT - 11:00 am CDT

Abstract: Latent cardiovascular toxicity issues continue to plague late-stage drug discovery efforts, as well as commercially launched pharmaceutical success. Many current in vitro models lack, or incompletely recapitulate, important aspects of human cardiac biology, thus allowing certain toxicities to escape detection until the non-human primate and clinical trial stages of drug development. Induced pluripotent stem cell (iPSC) technology brings relevant human biology to the laboratory and with it, great promise for early predictive detection of cardiotoxicity. This webinar will encompass…

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