SLAS2018 is the annual flagship International Conference and Exhibition from SLAS. Through a unique combination of education, access to innovative technologies and intelligent peer networking, SLAS2018 delivers unmatched value for professionals and students looking to discover the latest life sciences technologies and how they can be applied to drive research objectives.
Join us for a Cellular Dynamics Exhibitor Tutorial
Predictive Screening with iPSC-derived Cardiomyocytes and Neurons on High-speed/High-throughout Calcium Imaging
Monday, February 5 | 2:00 PM – 2:45 PM | Room 1A
Speaker: Beatriz Freitas, Field Application Scientist, Cellular Dynamics International – a Fujifilm Company
Human iPSC technology and the Hamamatsu FDSS/uCell screening platform bring relevant biology and predictive data acquisition to early drug discovery and toxicity screening efforts. Human cell types differentiated from induced pluripotent stem cells (iPSC) recapitulate normal and patho-physiological native cellular behavior while the FDSS/uCell platform enables phenotypic and mechanistic investigation at high throughput rates. This presentation will highlight recent advances demonstrating; (1) the ability for discovery-based screening in neurons and cardiomyocytes across several induced and patient-derived disease phenotypes (Parkinson’s, cardiac hypertrophy, etc) and (2) prediction and mechanistic resolution of proarrhythmia and drug-drug interactions for toxicity and safety pharmacology assessments. These case studies will demonstrate the ease of predictive screening with iPSC-derived tissue cells and Ca2+ imaging from Cellular Dynamics International and Hamamatsu, respectively while illustrating the value of using human material and functional readouts for early and accurate answers.