Products & Services

iCell® Hepatocytes

Investigate Liver Disease with Human Hepatocytes

The medical community needs a reproducible, well-characterized, and readily available source of human hepatocytes to advance significantly the launch of new metabolic and infectious disease therapies, reduce the incidence of drug-induced liver injury, and accelerate the development of novel approaches to liver regeneration and transplantation.

To meet this need, CDI has leveraged iPS cell technology  to develop iCell® Hepatocytes. These hepatocytes overcome the functionality, reproducibility, and availably limitations of existing primary cell and tumor-derived cell models by providing the following:

  • Relevant hepatic functionality and phenotypic stability
  • Expression of clinical targets that are relevant for liver and metabolic disease
  • Compatibility with a wide range of 3D and microphysiological systems
  • Quality-controlled manufacturing and batch reproducibility
  • Ready supply in a cryopreserved format

Proven Applications

iCell Hepatocytes are being rapidly adopted for use in a wide range of applications:

  • Diabetes research and drug discovery
    Functional insulin and glucose regulation pathways and a flexible product format enable high-throughput screening for novel drug candidates
  • Hepatotoxicity assessment
    Known genetic background and proven ability to detect metabolism-dependent and immune-mediated hepatotoxicity provide confidence in safety testing without the need for time-consuming and costly lot testing (See Sirenko, et al. 2013, Mann, 2014, Holmgren, et al., 2014)
  • Liver tissue engineering
    Compatibility with bioengineered scaffold engraftment, organ recellularization, and 3D printing enable new clinical and regenerative medicine strategies (See Berger, et al. 2015, Ware, et al. 2015)
  • Ordering Information
    Catalog # Description Quantity
    HCC-100-010-001 iCell Hepatocytes

    Cryopreserved iCell Hepatocytes

    >9 x 106
    Viable Cells/Vial
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    PHC-100-020-001 iCell Hepatocytes 2.0 Kit

    Each kit contains:

    • Cryopreserved iCell Hepatocytes
    • 3 ml iCell Hepatocytes Medium Supplement
    >9 x 106
    Viable Cells/Vial
    Request Quote